Central pain syndrome中枢性疼痛综合症

2007-1  

Cambridge Univ Pr  

Canavero, Sergio, M.D./ Bonicalzi, Vincenzo, M.D.  

382  

Central Pain Syndrome is a neurological condition caused by damage specifically to the central nervous system - brain, brainstem, or spinal cord. This is the only up-to-date book available on the clinical aspects (including diagnosis and therapy) of CPS management. The authors have developed a very complete reference source on central pain, which includes background material, pathophysiology, and diagnostic and therapeutic information. A medical mystery for 100 years with no effective cure, this book turns the concept of incurability of central pain on its head, providing a rational approach to therapy based on a rational theory. 　　作者简介：　　Sergio Canavero is the founder of Turin Advanced Neuromodulation Group, a think tank focused on the advancement of neuromodulation.　　Vincenzo Bonicalzi is a senior staff member at the Department of Neurosciences at the third largest medical facility in Italy.

List of TablesPreface (or, the Story of an Idea)1 Introduction　Definitions　History2　Central Pain of Brain Origin　Epidemiology and clinical features　　1. Lesions causing CP and location　　2. Incidence and prevalence　　3. Age of onset of CPSP　　4. Sex distribution of CPSP　　5. Time to pain onset　　6. Side of the lesions　　7. Size of the lesion and CPSP　　8. Pain distribution　　9. Quality of pain　　10. Intensity of pain　　11. Components　　12. Evoked pains　　13. Somatosensory findings　　14. Sympathetic and other signs and symptoms　 Special considerations　　1. Sensory epilepsy　　2. Parkinson's disease (PD)　　3. Iatrogenic lesions3 Central Pain of Cord Origin　　1. Lesions causing CCP　　2. Incidence and prevalence　　3. Age of onset and sex distribution　　4. Time to pain onset　　5. Level of lesion　　6. Distribution of pain　　7. Quality　　8. Intensity　　9. Components　 10. Evoked pains　　11. Somatosensory deficits　　12. Sympathetic and other signs and symptoms　　13. Course　Special considerations　　1. Syringomyelia　　2. Multiple sclerosis (MS)　　3. Spinal epilepsy4 Diagnosing Central Pain5 Drug Therapy　 Oral and parenteral drug therapy　　1. General comments　　　GABA drugs　　　Antiglutamatergic agents　　　Sodium channel blockers　　　Antidepressants　　　Opioids, naloxone and cannabinoids　　　Miscellaneous agents　　　Combinations　　2. Drug aggravation of CP6　Neuromodulation　　Electrical　　1. Extra- and subdural motor (MCS) and sensory cortex stimulation (PCS)　　　Mechanism of action　　2. Deep brain stimulation (DBS)　　　Mechanism of action　　　　a. PAG-PVG　　　　b. Vc　　　　c. Other areas　　　Efficacy　　　　a. Vc DBS　　　　b. PAG-PVG DBS　　3. Spinal cord stimulation　　　Mechanism of action　　　Efficacy　　……7 Pathophysiology:Human Data8 Piecing Together the EvidenceReferencesIndex

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