Foye医药学原理Foye＇s Principles of Medicinal Chemistry

2002-2  

Lippincott Williams & Wilkins  

David A Williams  

1114  

This comprehensive Fifth Edition has been fully revised and updated to meet the changing curricula of medicinal chemistry courses. The new emphasis is on pharmaceutical care that focuses on the patient, and on the pharmacist a therapeutic clinical consultant, rather than chemist. Approximately 45 contributors, respected in the field of pharmacy education, augment this exhaustive reference. New to this edition are chapters with standardized formats and features, such as Case Studies, Therapeutic Actions, Drug Interactions, and more. Over 700 illustrations supplement this must-have resource. Massachusetts College of Pharmacy and Health Sciences, Boston. Textbook, for pharmacy students, now includes an overview of the drug development process from the perspective of an industrial research scientist. Also new to this edition: an overview of drug receptors, case studies, selected readings, and a companion web page. Previous edition: c1995.

Introduction Origins of Medicinal ChemistryPart Ⅰ Principles of Drug Discovery　Overview Drug Design and Development: A Perspective 　1. Natural Products　 2. Drug Design and Relationship of Functional Groups to Pharmacologic Activity 　3. Molecular Modeling and Drug Design　 4. Receptors and Drug Action 　5. Drug Design Through Enzyme Inhibition　 6. Peptide and Protein Drugs 　7. Physicochemical and Biopharmacemical Properties of Drug Substances and Pharmacokinetics　 8. Drug Metabolism 　9. U.S. Drug Regulation: An OverviewPart Ⅱ Pharmacodynamic Agents Overview Drug Receptors: A Perspective　Section 1 Drugs Affecting Neurotransmission　　10. Drugs Affecting Cholinergic Neurotransmission　　11. Drugs Affecting Adrenergic Neurotransmission　　12. Serotonin Receptors and Drugs Affecting Serotonergic Neurotransmission　　13. Local Anesthetics　Section 2 Drugs Affecting Central Nervous System　　14. Volatile Anesthetics　　15. Hypnotics　　16. Antiseizure Drugs　　17. Psychotherapeutic Drugs: Antipsychotic and Anxiolytic Agents　　18. Hallucinogens, Stimulants, and Related Drugs of Abuse　　19. Opioid Analgesics 　　20. Drugs Used to Treat Neuromuscular Disorders: Antiparkinsonian and Spasmolytic Agents　Section 3 Drugs Affecting the Cardiovascular System　　21. Cardiac Agents: Cardiac Glycosides, Antianginal, and Antiarrhythmic Drugs　　22. Diuretics　　23. Angiotensin Converting Enzyme Inhibitors, Antagonists and Calcium Blockers　　24. Central and Peripheral Sympatholytics and Vasodilators ……Part Ⅲ Recent Advances in Drug DiscoveryAppendices pKa Values for Some Drugs and Miscellaneous Organic Acids and Bases pH Values for Tissue Fluids

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