Kirsner炎症性肠疾病
2003-12
Elsevier Science Health Science div
Sartor, R Balfour, M.D./ Sandborn, William J.
754
This comprehensive New Edition describes all of the latest scientific and clinical advances in the field of inflammatory bowel disease (IBD). A new editorial teamjoined by a superb group of international authoritiesexamine every aspect of IBDincluding etiology and pathogenesis, diagnosis and evaluation, medical and surgical therapy, and more. A wealth of expanded coverage, additional international contributors, extensive updating throughout, and numerous diagnostic and therapeutic algorithms make this an essential resource. Emphasizes evidence-based medicine in the section on medical therapy. Features a detailed description of inflammatory and immunologic pathways, allowing the reader to fully understand the contributing influences to the inflammation of IBD. Presents separate chapters on molecular genetics and clinical genetics for more in-depth coverage of each aspect of inflammatory bowel disease genetics. Provides a comprehensive review of IBD through abundant, high-quality endoscopic, radiographic, and histologic photographsplacing the various diagnostic modalities in perspective. Offers extensive coverage of postoperative recurrence of Crohn's disease · pouchitis · microscopic colitis · perianal disease · and osteoporosis. Includes up-to-the-minute guidance (including many 2003 references). Features a new editorial team, joined by numerous new contributors who provide fresh, global perspectives. Includes nine new chapters. Offers expanded coverage throughout, and through revisions of all pre-existing chapters. With over 75 additional contributing experts.
List of ContributorsForewordPrefaceSection I Mucosal protection and homeostasis 1.Intestinal epithelia barrier function: characteristics and responses to neutrophil transepithelial migration 2.Epithelial restitution and intestinal repair 3.Epithelial-microbial interactions 4.Immune cell-epithelial cell interactions 5.The regulation of mucosal homeostasis and its relation to inflammatory bowel diseases 6.T-lymphocyte trafficking 7.Leukocyte, platelet and endothelial cell interactions in the inflammatory bowel diseasesSection II Etiology and pathogenesis 8.Genetics: molecular and chromosomal considerations 9.Animal models of intestinal inflammation 10.Microbial influences in inflammatory bowel diseases: role in pathogenesis and clinical implications 11.Mechanisms of tissue injury 12.Cytokines and inflammatory mediators 13.T-lymphocyte dysregulation 14.Neuroimmune interactions in the inflamed intestine 15.Fibrogenesis 16.Colorectal cancer in inflammatory bowel disease:molecular considerationsSection III Epidemiology, clinical features and natural history 17.Epidemiology of inflammatory bowel diseases 18.Clinical genetics of inflammatory bowel diseases:genetic epidemiology, genotype-phenotype correlations and pharmacogenetics 19.Clinical course and natural history of ulcerative colitis 20.Clinical features and natural history of Crohn's disease 21.Clinical features and natural history of pediatric inflammatory bowel diseases 22.Physiologic consequences of surgical treatment for inflammatory bowel disease 23.Fertility and pregnancy 24.Psychosocial factors in ulcerative colitis and Crohn's diseaseSection IV Diagnosis and evaluationSection V Medical therapySection VI Surgical therapySection VII Complications and associated diseasesIndex
