颅脑MR灌注影像 Cerebral MR Perfusion Imaging

2000-8  

Thieme Publishing Group (2000年8月23日)  

A.Gregory Sorenson  

152  

Cerebral hemodynamics - what are they? How can I use MRI to measure cerebral perfusion in a clinical setting? What tumors have high blood volume? Can perfusion imaging help define the ischemic penumbra? What should I do if I want to image perfusion in the presence of a leaky BBB? From the basic principles of perfusion MR imaging to present clinical applications in the assessment of cerebrovascular diseases and intra-cranial tumors this book provides practical information for newcomers to this technique as well as experienced radiologists.

Table of ContentsPreface Acknowledgements List of Abbreviations List of Movie Clips Part 1: Technical Considerations Introduction Cerebral hemodynamics - what are they? Perfusion MRI with dynamic susceptibility contrast imaging Why is magnetic susceptibility so powerful? Why use contrast agents? Bolus injection versus slow infusion of contrast agent Why is the status of the BBB important for Perfusion MRI? How do I image perfusion in the presence of a leaky BBB? Advantages of available and future contrast agents What about non-contrast techniques? Why use rapid imaging techniques? Should I use spin echo or gradient echo EPI? What are the detailed typical parameters for perfusion imaging? Non-EPI Systems EPI Systems Can you tell me more about the optimum contrast agent dose? Do I need a power injector? How do I use it? How do I perform a manual injection? Is the injection volume important? Is field strength important? How do I postprocess perfusion images? Overview Step 0: Before you start Step 1 : The initial parameter of concentration versus time Step 2: Analyzing the curve Step 3: Creating the maps: CBV Step 4: Creating the maps: CBF Step 5: Creating the maps: MTT and other timing maps What advanced techniques may become important in the future? Compensation for delay and dispersion Flow heterogeneity Average vessel diameter Part 2: Perfusion Imaging in Clinical Practice Perfusion MRI compared to other routine modalities Perfusion MRI in cerebrovascular disease Acute stroke Stroke pathophysiology and imaging of blood flow Practical perfusion MRI in acute stroke Reperfusion Chronic stroke Moya-moya lntraparenchymal hemorrhage Intracranialtumors Rationale for perfusion MRI Diagnosis Direction of biopsy/intervention Treatment follow-up Dementia Vasospasm Head trauma Migraine Epilepsy Otherlesions Conclusion References Selected reading Perfusion methodology Clinical applications: ischemia Clinical applications: tumors Clinical applications: other areas Non-contrast perfusion methodology Perfusion MRI in animal studies Cited papers Index CD-ROM Instructions

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