基因与信号
2003-8
清华大学出版社
普坦森
192
我国的生命科学与生物技术和美国、日本等发达国家相比还有较大差距，存在生命科学基础理论研究不够深入扎实、学术创新能力不强、拥有自主知识产权的生物技术产品种类少、产量低、生物技术产业规模小、相关配套产业社会化程度低等问题。为了高等院校师生和广大科技人员借鉴和学习发达国家生命科学与技术的先进理论和技术，提高我国在生物经济方面的竞争力，我们精选了一批国外优秀生命科学与生物技术著作，组织专家进行了评阅和审核，希望能对高等院校师生和广大科技人员有所帮助，同时对我国生命科学和生物技术产业赶超世界先进水平起到一定的推动作用。
PrefaceForewordIntroductionCHAPTER 1 Lessons from Bacteria RNA POLYMERASE REGULATED RECRUITMENT:THE/ac GENES Protein-DNA Interactions Detecting Physiological Signals promoter Recognition and Transcription by RNA Polymerase Switching the Genes On:Activation by CAP Cooperative Binding of Proteins to DNA Cooperative Binding and Gene Activation by CAP Repression by Lac Repressor Interim Summary and Extension MORE REGULATED RECRUITMENT:THE BACTERIOPHAGE The Switch Establishing Lysogeny Analogies with lac promoters Protein-DNA interactions Repression Activation Detecting Physiological Signals Making an Efficient Switch Cooperative Binding of Repressor to DNA Autogenous Control by Repressor PANEL:Antitermination:N and Q Interim Summary and Extensions Activation :A Closer Look DNA binding:A Closer Look Synergy POLYMERASE ACTIVATION:glnA AND RELATED GENES Promoter Recognition by containing Ploymerase DNA Binding by NtrC Detecing the Physiological Signal Activation by NtrC Other Activatjors of Polymerase Interim Summary PANEL:Phage T4 Late Genes PROMOTER ACTIVATION:merT AND RELATED GENES Promoter Recognition Detection the Physiological and Activation Interim Summary GENERAL SUMMARY PANEL:more on Repression in Bacteria FOOTNOTES BIBLIOGRAPHYCHAPTER 2 Yeast:A single-celled Eukaryote……CHAPTER 3 Some Note on Higher EukaryotesCHAPTER 4 Enyme Specificity and RegulationAfterwordAppendicesAppendix1:More on CooperativityApperdix2:Topogenic SepuencesAppendix3:All-or-none Effects and Levels of Gene ExpressionIndex
