基于核酸治疗的药物的前景Pharmaceutical Perspectives of Nucleic acid-based Therapeutics

2002-6  

Oversea Publishing House  

Mahato, Ram I.; Kim, Sung WAN;  

521  

Pharmaceutical Perspectives of Nucleic Acid-Based Therapy presents a comprehensive account of gene therapy, from development in the laboratory to clinical applications, with an emphasis on cancer and cardiovascular and autoimmune diseases. Internationally acclaimed scientists discuss the potential use of lipids, peptides and polymers for the in vivo delivery of nucleic acids, the genesis of structure-synthesis-function interrelationships and the evolutionary approaches of these gene carriers. The book also addresses the influence of a viable gene expression system on disease by controlling gene regulation, transcription, translation and replication. Univ. of Tennessee, Memphis. Presents a comprehensive account of design and modulation of gene expression and nucleic acid delivery systems. Includes the possible use of lipids, structure-synthesis-function relationship, and the use of DNA and devices for gene delivery. Contains color plates and halftone illustrations. For research scientists.

Ram Mahato is at the University of Tennessee in Memphis, USA and Sung Wan Kim is at the University of Utah, USA.

List of color platesList of figuresList of tablesList of contributorsForewordPreface1 Basic components of gene expression plasmids2 Inducible gene expression strategies in gene therapy3 Modulation of gene expression by antisense oligonucleotides4 Ribozymes as therapeutic agents and genetic tools5 Peptide nucleic acids (PNA) binding-mediated target gene transcription6 Aptamers for controlling gene expression7 Enzymes acting on DNA breaks and its relevance in nucleic acid-based therapy8 Compaction and condensation of DNA9 Structure, dispersion stability and dynamics of DNA and polycation complexes10 Structure and structure-activity correlations of cationic lipid/DNA complexes: supramolecular assembly and gene delivery11 Cellular uptake, metabolic stability and nuclear translocation of nucleic acids12 Nucleocytoplasmic trafficking13 Optimizing RNA export for transgene expression14 Naked plasmid DNA delivery of a therapeutic protein15 Cationic lipid-based gene delivery16 Peptide-based gene delivery systems17 Cationic and non-condensing polymer-based gene delivery18 Device-mediated gene delivery19 Basic pharmaeokinetics of oligonucleotides and genes20 Interstitial transport of macromolecules: implication for nucleic acid delivery in solid tumors21 Hepatic delivery of nucleic acids using hydrodynamics-based procedure22 Role of CpG motifs in immunostimulation and gene expression23 Local cardiovascular gene therapy24 Gene therapy for cardiovascular disease25 Gene therapy for the prevention of autoimmune diabetes List of color plates

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