有机药学与制药Organic Medicinal and Pharmaceutical

2003-12  

Lippincott Williams & Wilkins  

Wilson, Charles Owens (EDT)/ Beale, John Marlowe (EDT)/ Block, John H. (EDT)/ Block, John H./ Gisvold, Ole (EDT)  

991  

For over half a century, this book has served the discipline of medicinal chemistry for both graduate and undergraduate pharmacy and chemistry students as well as practicing pharmacists. Fully updated for the Eleventh Edition, coverage begins with the fundamental principles of chemistry, biochemistry, and biology that underlie the discipline of medicinal chemistry. These principles are then applied to understanding the properties, mode of action, therapeutic applications, and limitations of various pharmaceutical agents. The subject matter is organized by pharmaceutical and therapeutic classes, providing a bridge between the basic sciences and clinical practice. The text contains many tables for quick reference to names, formulations, dosages, and applications.

Preface Contributors CHAPTER 1 Introduction CHAPTER 2 Physicochemical Properties in Relation to Biological Action CHAPTER 3 Combinatorial Chemistry CHAPTER 4 Metabolic Changes of Drugs and Related Organic Compounds CHAPTER 5 Prodrugs and Drug Latentiation CHAPTER 6 Biotechnology and Drug Discovery CHAPTER 7 Immunobiologicals CHAPTER 8 Anti-infective Agents CHAPTER 9 Antimalarials CHAPTER 10 Antibacterial Antibiotics CHAPTER 11 Antiviral Agents CHAPTER 12 Antineoplastic Agents CHAPTER 13 Agents for Diagnostic Imaging CHAPTER 14 Central Nervous System Depressants CHAPTER 15 Central Nervous System Stimulants CHAPTER 16 Adrenergic Agents CHAPTER 17 Cholinergic Drugs and Related Agents CHAPTER 18 Diuretics CHAPTER 19 Cardiovascular Agents CHAPTER 20 Local Anesthetic Agents CHAPTER 21 Histamine and Antihistaminic Agents CHAPTER 22 Analgesic Agents CHAPTER 23 Steroids and Therapeutically Related Compounds CHAPTER 24 Prostaglandins, Leukotrienes, and Other Eicosanoids CHAPTER 25 Proteins, Enzymes, and Peptide Hormones CHAPTER 26 Vitamins and Related Compounds CHAPTER 27 An Introduction to the Medicinal Chemistry of Herbs CHAPTER 28 Computational Chemistry and Computer-Assisted Drug Design App Calculated Log P, Log D, and pK[subscript alIndex

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