信号转导手册
2011-6
科学出版社
布拉德肖
384
Ralph
A.Bradshaw编著的《信号转导手册(1细胞内外信号转导机制原著第2版导读版)(精)》包含350个章节，全面涵盖细胞信号转导领域。内容包括：细胞内外信号转导机制，蛋白质磷酸化和去磷酸化，钙离子信号转导、脂质介导的第二信使，蛋白质互作、环化核苷酸，G蛋白、发育生物学中的信号转导，转录与翻译：细胞核与细胞质事件．细胞内功能区隔信号转导、胞间和细胞基质问的相互作用、疾病病理学。
《信号转导手册(1细胞内外信号转导机制原著第2版导读版)(精)》是生物学实验室不可或缺的工具用书，适用于生物化学与分子生物学、细胞生物学等相关专业的高年级本科生、研究生．也可作为教师的教学和科研参考书，亦可供生物医学、药理学、免疫学及相关领域的研究人员参考。
英文目录
撰稿人名单
第二版前言
第一版前言
导读版第①卷 细胞内外信号转导机制
l．细胞信号转导：昨天、今天和明天
第一部分 起始：胞外及质膜事件
A 分子识别
2．分子识别的结构和能量基础
3．蛋白与蛋白相互作用的自由能概貌
4．分子社会学
5．抗原一抗体识别及其构象变化
6．抗原一抗体界面处的结合热力学
7．免疫球蛋白-Fc受体相互作用
8．免疫球蛋白超折叠及其在分子识别中的多种用途
9．T细胞受体／pMHc复合体
10．细胞表面黏附受体的机制特征
11．免疫突触
12．NK受体
13．碳水化合物的识别与信号转导
14．鼻病毒与其受体的相互作用
15．卜型人免疫缺陷病毒与其受体的相互作用
16．流感病毒神经氨酸酶的抑制剂
17．涉及血液纤维蛋白原及纤维蛋白的信号事件的结构基础
18．整合素信号的结构基础
19．G蛋白异源三聚体及其复合物的结构
20．G蛋白偶联受体的结构
21．Toll样受体的结构与信号
22．多种多样的淋巴细胞受体
B 多通路受体
23．G蛋白偶联受体的结构与功能：从最近发现的晶体结构得到的启示
24．趋化因子及其受体的结构与功能
25．G蛋白偶联受体的结构及其被可扩散激素所激活的过程(参照β2型肾上腺素受体模型)
26．蛋白酶激活的受体
27．由激动剂导致的G蛋白偶联受体的脱敏及细胞内吞化作用
28．由G蛋白偶联受体形成的二聚化复合体的功能
29．细菌中的趋化性受体：跨膜信号，敏感性，匹配及受体聚集
30．离子通道结构概论
31．STIM和Orai介导的钙库依赖性钙信号及CRAC离子通道激活的分子机制
32．离子渗入性：离子选择性与进入阻断的机制
33．烟碱乙酰胆碱受体
34．与核苷酸环化酶直接结合而被调节的离子通道
C 对受体的横向比较研究
35．细胞因子受体概述
36．生长激素与泌乳激素家族及其受体：受体激活和调节的结构基础
37．以促红细胞生成素受体为例的细胞因子信号
38．纤维原细胞生长因子(FGF)信号复合体
39．γ干扰素及其受体的结构
导读版第2卷 蛋白质磷酸化和去磷酸化
导读版第3卷 钙离子信号转导、脂质介导的第二信使
导读版第4卷 蛋白质互作、环化核苷酸
导读版第5卷 G蛋白、发育生物学中的信号转导
导读版第6卷 转录与翻译：细胞核与细胞质事件
导读版第7卷 细胞内功能区隔信号转导、胞间和细胞基质间的相互作用、疾病病理学
索引
Mechanistic Features of Cell-Surface Adhesion Receptors Living cells constantly interact with their environment.Asa consequence，a number of sensory systems have evolvedfor the collection，processing，and integration ot a remark-able range of environmental stimuli arising from cell-celland cell-substrate interactions.For instance，developmentaland morphological processes in higher eukaryotes rely onthe orchestrated migration of cells in response to specificphysical and chemical cues；T cell activation relies on thelocalization and comDartmentalization of cell-adhesion andsignaling molecules；and adherent cells must respond to avariety of intracellular and extracellular mechanical forces.All of these processes rely on the engagement ot spemhc cell-surface receptors with the appropriate extracellularligand to report on the immediate physical environment bytransducing extracellular signals across the plasma mem-brane.This review examines the diversity of mechanismsthought to be involved in adhesion and signaling and high-1ights some of the shared principles that must be consideredfor all signaling pathways utilizing cell-surface receptors. MECHANOSENSORY MECHAN ISMS The ability to detect and respond to alterations in applied mechanical force is required for a number of cellular and developmental functions.This is particularly critical for adherent cells that directly contact the extracellular matrixfECM）and are subject to considerable physical deforma-tion.For example，sheer forces associated with blood flow are maior determinants of arterial tone and vascular reorgan-ization.At the cellular level，morphology and orientation are optimized to minimize mechanical stress and damage asso-ciated with variations in flow-related forces（see，for exam-ple，（1-31）.Similarly,fibroblasts must be highly responsive Handbook of Cell Signaling，Three-Volume Set 2 ed-Copyright 0 2010 Elsevier Inc All rights reservedto the mechanical forces associated with alterations in theECM（reviewed in 141）. Considerable evidence points to focal adhesions，thesites of cell-substrate contact，as the sensors of mechanicalforce.Central to focal adhesion assembly and function arethe integrins.a family of α-βheterodimeric transmembraneglycoproteins that provide essential adhesive functions forcell migration and the establishment and maintenance of nor-mal tissue architecture.At least 18α and 8β chains allow forthe formation of multiple integrin heterodimers that are ableto display a spectrum of specificities for cell-surface adhesion molecules and for a range of ECM components，includingLaminin，collagen，and fibronectin.The integrin cytoplas-mic domains bind a variety of scaffolding and actin regula-tory proteins.which in tum recruit a large number of adaptor and signaling molecules.These physical links couple theintegrins to the downstream activation of numerous sxgnal-ing molecules，including MAP kinase，focal adhesion kinase，Src.and P13-kinase（see，for example，（4，51）.Furthermore，integrin affinity is modulated by the activation state of the particular cell in question.
买回来才知道是英文版的。当时没留意看，不过也很不错。 要是英文字有点小，大点就好了，看起来会更舒服！