医学免疫学
2008-2
人民卫生
何维,等
442
743000
Essential Medical Immunology is written for medical students in the People's Republic of China and is adapted largely from Immunology (Seventh Edition) by David Male, Jonathan Brostoff, David B Roth and Ivan Roit, with the permission of Mosby Elsevier Publishers. Information from other sources,including research articles, has also been included. Immunology is an experimental biomedical science concerned with the study of the structure and function of the immune system in all life-forms, while medical immunology emphasizes on the human system and the diseases associated with it. Starting from the pioneering observations of people like Edward Jenner, who in 1798 performed the first vaccination, or Frank Widal who, in 1896, developed the first serological test, immunology has grown enormously to become an important, complex discipline that has permeated into many other fields of biology, including such diverse areas as neuroscience and biotechnology. The book attempts to provide a brief account of immunology to medical students and is divided broadly into ' Basic Immunology and Clinical Immunology'. Although the aim is to keep the text simple and concise, depth has been given to some areas to provide a more comprehensive understanding for the more enthusiastic students. We hope students will find the book both informative and user-friendly. We are indebted to Associate Profess~6r Yang Gao, Ms. Xianqian Kong and Ms. Peggy Fung for their secretarial assistance.
Section I Basic Immunology Chapter 1 Overview of the Immune System INNATE IMMUNITY Physical and Chemical Barriers Phagocytic Cells Auxiliary Cells Soluble Mediators Complement Proteins Toll-like Receptors ADAPTIVE IMMUNITY B and T Cells Cytokines Specific Immune Responses Three Phases of Immune Responses Crosstalk between Innate and Adaptive Immunity IMMUNOPATHOLOGY inflammation and Tissue Injury Allergen-induced Immunopathology Autoantigen-induced Immunopathology IMMUNOLOGICAL APPLICATIONS Vaccination Immunotherapys and immunoassays Chapter 2 Cells, Organs and Tissues of the Immune System IMMUNE CELLS Innate Immune Cells Adaptive Immune Cells IMMUNE CELL SURFACE RECEPTORS FOR ANTIGENS Pattern-recognition Receptors on Innate Immune Cells B Cell Receptor on B Cells T Cell Receptor on T Cells MHC Molecules IMMUNE ORGANS AND TISSUES Primary Lymphoid Organs-Bone Marrow and Thymus Secondary Lymphoid Organs and Tissues-Spleen, Lymph Nodes Chapter 3 Soluble Mediators of the Immune System ANTIBODIES Structure of lmmunoglobulins Bifunctional Activities of lmmunoglobulins A Vast Repertoire of Antigen-binding Sites Somatic Hypermutation and Affinity Maturation COMPLEMENT Complement Activation Pathways Complement-mediated Inflammatory Reaction CYTOKINESChapter 4 The Innate Immune Response COMPONENTS OF INNATE IMMUNITY Physical and Chemical Barriers Phagocytic Cells, NK cells, Blood Proteins and Cytokines and MALT RECOGNITION OF INNATE IMMUNITY Pattern Recognition Receptors and Pathogen-associated Molecular Patterns .. NK Cells Recognition via Their Inhibitory Receptors and Activating Receptors RESPONSE MODELS OF INNATE IMMUNITY Cytotoxicity to Target Cells Killing Microbes and Inflammation Chapter 5 The Adaptive Immune Response ANTIGEN PRESENTATION Types of APCs Antigen Processing Exogenous Peptides Presented by MHC Class II and Endogenous Peptides Presented by MHC Class Co-stimulatory Molecules for T Cell Activation Immunological Synapse Antigen Presentation and the Course of an Immune Response ACTIVATION OF T AND B LYMPHOCYTES B Ceils Responses to TI or TD Antigens Signal Transduction in T and B Cell Activations The Interaction between B Cells and TH Cells : Proliferations and Differentiations of Activated T and B Cells……
